Purinergic receptors are the ones that use nucleotides as their agonists or antagonists. They have crucial role in platelets. Their physiological role as well as pharmacological target for antiplatelet drugs are well established and they have immense applications in clinical practice. But today the same purinergic receptors over platelets were identified elsewhere and they have been implicated in various health conditions. So, this review focuses to explain the non-thrombotic uses of platelet purinergic receptors