Abstract
Epilepsy, characterized by recurrent seizures, encompasses various
complex syndromes with varied origins. To unravel the intricate biology
of epilepsy and explore novel Antiseizure treatments, researchers have
developed over 100 in vitro and in vivo epilepsy models, each simulating
different seizure types. These experimental models serve as
indispensable tools for investigating the neurochemical,
neurophysiological, cellular, and molecular mechanisms governing
epileptic seizures, offering a comprehensive understanding of this
condition. This article provides a comprehensive overview of diverse
experimental models crucial for studying Antiseizure Medication and
seizures, including Generalized Tonic-Clonic Seizure (GTCS), Temporal
Lobe Epilepsy (TLE), Absence Seizure, Myoclonus, and Status Epilepticus
(SE) Models. Researchers leverage these models to gain critical insights
into epilepsy’s underlying causes, available therapies, and potential
therapeutic targets. The study digs into a thorough analysis of the
benefits and drawbacks related to various chemical models used in
epilepsy treatment. This dual approach adds to the continuing discussion
in epilepsy research by clarifying the complicated issues surrounding
therapeutic strategies and improving our understanding of the complexity
of epilepsy. This article includes discusses GTCS, SE, and TLE subtypes
such as WAG/Rij rats, coriaria lactone-induced TLE, pilocarpine-induced
TLE, Tottering 6j mouse, GHB-induced seizure model, PTZ-induced model,
NMDA-induced seizure models, and flurothyl-induced seizure model.
Penicillin-induced TLE, Theiler’s virus-induced TLE, and many more.