1. Introduction
Epilepsy is a neurological condition marked by recurrent seizures. A seizure is typically described as an abrupt shift in behavior brought on by a transient disruption in the electrical activity of the brain. The brain typically continuously produces minute electrical impulses that follow a predictable pattern. Epilepsy is world’s most prevalent chronic neurologic disorders, epilepsy is thought to impact nearly 70 million individuals globally [1] . Females and males experience the exact prevalence (46.2 per 100,000 against 50.7 per 100,000)[2] . In the US, 1.2% of the population, including more than 500,000 women of reproductive age, have an active epilepsy diagnosis [3] . One of the most prevalent neurologic conditions that typically necessitates ongoing therapy is epilepsy[4] . EEG abnormalities and clinical abnormalities are frequently seen in conjunction [5] . Recurrent seizure events can damage neurons and necrosis [6] . Cerebral dysfunction worsens, and potentially fatal consequences significantly burden the patients’ families [7] .
Animal models play a crucial part in comprehending the biology of epilepsy, including developing novel Antiseizure medications[8]. Even though several novel Antiseizure medicines (ASMs) have been developed successfully in recent years, finding new treatments that are more effective and tolerable is still a top priority