6.1.3 Coriaria Lactone Induced TLE
An experimental paradigm for studying epilepsy is coriaria lactone-induced temporal lobe epilepsy (TLE). Animal subjects, primarily rodents, are given Coriaria lactone, a substance produced from the Coriaria plant, to cause TLE-like seizures [48] . Repeated intramuscular/intraperitoneal injections (median 48) of Coriaria lactone (0.75-2 mg/kg) serve as a kindling TLE model in Rhesus monkeys, indicating a primate animal model of epileptogenesis. Resemblance of TLE’s behavioral, electrographic, and anatomical traits were produced using this Model.
Advantages: This Model is used by researchers to examine how epilepsy alters neuronal excitability, neurotransmitter activity, and neuroinflammation in primates.
Disadvantages: Animal seizures brought on by coriaria lactone may resemble TLE in specific ways, but they might not completely capture the complexity and diversity of human epilepsy.