6.2.1 Controlled cortical impact TLE model
The purpose of developing the testing platform for the controlled cortical impact (CCI), a mechanical model of traumatic brain injury (TBI). CCI is made with the help of an electromagnetic piston with set parameters. Tip diameter – 6 to 8 mm, Velocity – 4 m/s, Dwell time – 50 to 250 ms, Depth – 1 to 2 mm. In addition, significant long-term pathological effects have been seen, including delayed hippocampal lesions and mossy fiber sprouting, considered hallmark TLE symptoms. CCI models are as certified as possible TLE models [51] . The CCI model has a short latent period, spontaneous seizures, and is repeatable.
Advantages: The temporal lobe epilepsy (TLE) symptoms of delayed hippocampal lesions and mossy fiber sprouting have been demonstrated in the Model as significant long-term pathological effects. This increases its usefulness for researching TLE.
Disadvantages: The relatively short period of the CCI model may restrict its potential to reflect the complete range of TBI outcomes, particularly those that evolve or deteriorate over time. It’s complicated and requires a specialized instrument.