6.1.2 Pilocarpine Induced TLE
This Model has been used to evaluate the long-term effectiveness of new
treatments for reducing SRS and enhancing the cognitive and
neuropathological changes brought on by severe mTLE. Many of the
neuropathological characteristics of mTLE, such as severe seizures, the
loss of GABAergic interneurons in the dentate gyrus, Ammon’s Horn
sclerosis, and cognitive deficits, are recapitulated in this mouse model
of TLE [47] .