6.1.1 KA-Induced TLE
KA is an ionotropic KA receptor agonist and a cyclic analog of
L-glutamate. Acute seizures are characterized by symptoms comparable to
those seen after intrahippocampal injections following intra-amygdaloid
injections of KA (0.4-2 g) in rats [46] . In monkeys,
however, intracerebral administration of KA (0.5-10 μg/μl of saline) in
the hippocampus or the amygdala does not produce generalized seizures
but is linked to focal seizures.
Advantages: The main benefit of administering KA systemically
instead of intracerebrally is that more animals can be injected
simultaneously with fewer complications.
Disadvantages: The way different species react to KA
treatment can differ. This calls into doubt the Model’s applicability
to epilepsy in humans.