6.2.1 Controlled cortical impact TLE model
The purpose of developing the testing platform for the controlled
cortical impact (CCI), a mechanical model of traumatic brain injury
(TBI). CCI is made with the help of an electromagnetic piston with set
parameters. Tip diameter – 6 to 8 mm, Velocity – 4 m/s, Dwell time –
50 to 250 ms, Depth – 1 to 2 mm. In addition, significant long-term
pathological effects have been seen, including delayed hippocampal
lesions and mossy fiber sprouting, considered hallmark TLE symptoms. CCI
models are as certified as possible TLE models [51] . The
CCI model has a short latent period, spontaneous seizures, and is
repeatable.
Advantages: The temporal lobe epilepsy (TLE) symptoms of
delayed hippocampal lesions and mossy fiber sprouting have been
demonstrated in the Model as significant long-term pathological
effects. This increases its usefulness for researching TLE.
Disadvantages: The relatively short period of the CCI model
may restrict its potential to reflect the complete range of TBI
outcomes, particularly those that evolve or deteriorate over time.
It’s complicated and requires a specialized instrument.