1. Introduction
Epilepsy is a neurological condition marked by recurrent seizures. A
seizure is typically described as an abrupt shift in behavior brought on
by a transient disruption in the electrical activity of the brain. The
brain typically continuously produces minute electrical impulses that
follow a predictable pattern. Epilepsy is world’s most prevalent chronic
neurologic disorders, epilepsy is thought to impact nearly 70 million
individuals globally [1] . Females and males experience the
exact prevalence (46.2 per 100,000 against 50.7 per 100,000)[2] . In the US, 1.2% of the population, including more
than 500,000 women of reproductive age, have an active epilepsy
diagnosis [3] . One of the most prevalent neurologic
conditions that typically necessitates ongoing therapy is epilepsy[4] . EEG abnormalities and clinical abnormalities are
frequently seen in conjunction [5] . Recurrent seizure
events can damage neurons and necrosis [6] . Cerebral
dysfunction worsens, and potentially fatal consequences significantly
burden the patients’ families [7] .
Animal models play a crucial part in comprehending the biology of
epilepsy, including developing novel Antiseizure medications[8]. Even though several novel Antiseizure medicines (ASMs)
have been developed successfully in recent years, finding new treatments
that are more effective and tolerable is still a top priority