6.1.2 Pilocarpine Induced TLE
This Model has been used to evaluate the long-term effectiveness of new treatments for reducing SRS and enhancing the cognitive and neuropathological changes brought on by severe mTLE. Many of the neuropathological characteristics of mTLE, such as severe seizures, the loss of GABAergic interneurons in the dentate gyrus, Ammon’s Horn sclerosis, and cognitive deficits, are recapitulated in this mouse model of TLE [47] .