The results of the investigation of the exact nature of the mechanisms that ensure the organism's survival in the face of the pathogen's pathological effects reveal those severe co-occurring manifestations that are temporally linked to a pathogen, such as those which appear in COVID-19 patients, to be manifestations of different diseases which are brought about through the same pathway under the influence of different causes which include the pathogen. Since the single pathway through which all of such diseases, which have the same "immunological nature," are brought about must be blocked for the attenuation of the influence of the pathogen to bring about the remission of the disease it causes, such diseases will undergo simultaneous remission when conditions permit immune mechanisms to attenuate the causative influences of the pathogen. Therefore, when conditions do not permit immune mechanisms to attenuate the influence under which any of the diseases in the same "immunological spectrum" as the disease the pathogen causes is produced through the pathway, the manifestations of such diseases that are linked with the pathogen will persist despite treatments that reduce pathogen load and the pathogen will appear to be resistant to treatment. These results throw light on the different immunological phenomena which include those that inspired variolation and vaccination, remissions that are temporally linked with infection, the multiorgan manifestations that are seen in COVID-19 as well as long COVID.