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NRF2 signaling in cytoprotection and metabolism
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  • Shohei Murakami,
  • Yusuke Kusano,
  • Keito Okazaki,
  • Takaaki Akaike,
  • Hozumi Motohashi
Shohei Murakami
Tohoku Daigaku
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Yusuke Kusano
Tohoku Daigaku
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Keito Okazaki
Tohoku Daigaku
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Takaaki Akaike
Tohoku University Graduate School of Medicine
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Hozumi Motohashi
Tohoku Daigaku

Corresponding Author:[email protected]

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The KEAP1-NRF2 system plays a central role in cytoprotection and defense mechanisms against oxidative stress. Because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and because NRF2 is a transcriptional factor regulating genes involved in the sulfur-mediated redox reactions, the KEAP1-NRF2 system has been regarded as a sulfur-utilizing cytoprotective mechanism. NRF2 is a key regulator of cytoprotective genes, such as antioxidant and detoxification genes, and also to possess potent anti-inflammatory activity. NRF2 has been recently focused as a great modifier/regulator for the cellular metabolism and mitochondrial function. Particularly, the NRF2-mediated regulatory mechanisms of metabolites and mitochondria has been considered diverse, but has not been fully-clarified yet. This review article provides an overview of the molecular mechanisms that regulate NRF2 signaling and its cytoprotective roles, and also highlights NRF2 contribution to the cellular metabolism, particularly in the context of mitochondrial function and newly found sulfur metabolism.
07 Jul 2023Submitted to British Journal of Pharmacology
07 Jul 2023Submission Checks Completed
07 Jul 2023Assigned to Editor
12 Jul 2023Reviewer(s) Assigned
03 Aug 2023Review(s) Completed, Editorial Evaluation Pending
03 Aug 2023Editorial Decision: Revise Minor
13 Aug 20231st Revision Received
14 Aug 2023Assigned to Editor
14 Aug 2023Submission Checks Completed
25 Aug 2023Reviewer(s) Assigned
28 Aug 2023Review(s) Completed, Editorial Evaluation Pending
29 Aug 2023Editorial Decision: Revise Minor
01 Sep 20232nd Revision Received
01 Sep 2023Submission Checks Completed
01 Sep 2023Assigned to Editor
05 Sep 2023Reviewer(s) Assigned
08 Sep 2023Review(s) Completed, Editorial Evaluation Pending
09 Sep 2023Editorial Decision: Accept