Figure 2. Domain structures of NRF2 and KEAP1.
NRF2 consists of 6 functional domains, Neh1 to Neh6. The function of each Neh domain is shown on the top of the NRF2 structure and some representative factors binding to each domain are also shown. Two serine residues (Ser344 and Ser347) of murine NRF2 are phosphorylation target sites of GSK3. KEAP1 has three domains. Their function is shown on the top of the KEAP1 structure. Three cysteine residues (Cys151, Cys273 and Cys288) of murine KEAP1 are major functional target sites of electrophiles.