An Update on the Review of Microbial Synthesis of Glucosamine and
N-acetylglucosamine
Abstract
Glucosamine (GlcN) is a natural amino monosaccharide in which a hydroxyl
group of glucose is substituted for an amino group. It belongs to
functional amino sugar compounds. The traditional GlcN production method
is prepared by hydrolyzing the exoskeleton of shrimp and crab. This
method has many potential problems such as geographical and seasonal
restrictions on raw material supply, serious environmental pollution and
potential allergic reactions. The microbial fermentation method has the
advantages of short fermentation time, high production intensity, wide
source of raw materials, green and sustainable process, and product
safety. This paper mainly summarizes the research on strain
construction, metabolic pathway design, and fermentation condition
optimization in microbial fermentation, which has certain guiding
significance for the further production of glucosamine.