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Hospitalization Rate of Respiratory Syncytial Virus associated Acute Lower Respiratory Infection among Young Children in Suzhou, China, 2010-2014
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  • Shaolong Ren,
  • Ting Shi,
  • Wei Shan,
  • Si Shen,
  • Qinghui Chen,
  • Jian Xue,
  • Zirui Dai,
  • Wanqing Zhang,
  • Tao Zhang,
  • Jianmei Tian,
  • Genming Zhao
Shaolong Ren
Fudan University School of Public Health

Corresponding Author:[email protected]

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Ting Shi
Soochow University Affiliated Children's Hospital
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Wei Shan
Fudan University School of Public Health
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Si Shen
Fudan University School of Public Health
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Qinghui Chen
Soochow University Affiliated Children's Hospital
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Jian Xue
Soochow University Affiliated Children's Hospital
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Zirui Dai
Fudan University School of Public Health
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Wanqing Zhang
Fudan University School of Public Health
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Tao Zhang
Fudan University School of Public Health
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Jianmei Tian
Soochow University Affiliated Children's Hospital
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Genming Zhao
Fudan University School of Public Health
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Abstract

Background: Data on disease burden of respiratory syncytial virus (RSV) associated acute lower respiratory infection (ALRI) among young children are limited in China. This study aimed to estimate the hospitalization rate of RSV-associated ALRI (RSV-ALRI) among children aged 0~59 months in Suzhou, China. Methods: We retrospectively identified all hospitalized ALRI children aged 0~59 months in Suzhou University Affiliated Children’s Hospital during January 2010 to December 2014. Detailed diagnosis and treatment data were collected by individual medical chart review. Referring to WHO influenza disease burden estimation method, we estimated the hospitalization rate of RSV-ALRI among children aged 0~59 months in Suzhou, China. Results: Among 28,209 ALRI cases, 19,317 (68.5%) were tested for RSV and the RSV positive proportion was 21.3% (4,107/19,317). The average hospitalization rate of RSV-ALRI for children aged 0~59 months was 14 (95% confidence interval [CI]:14~14)/1,000 children-years, for children aged 0~5, 6~11, 12~23, and 24~59 months were 70 (95%CI: 67~73), 31 (95%CI: 29~33), 11 (95%CI: 10~12), and 3 (95%CI: 3~3) /1,000 children-years, respectively. Conclusion: There is considerable RSV-ALRI hospitalization among children aged 0~59 months, particularly among children aged <1 years. An effective monoclonal antibody or vaccine is urgently needed to address the substantial hospitalization burden owing to RSV infection. Key words: Respiratory syncytial virus, Hospitalization rate, Acute lower respiratory infection, Children, China
19 Nov 2021Submitted to Influenza and other respiratory viruses
23 Nov 2021Submission Checks Completed
23 Nov 2021Assigned to Editor
05 Dec 2021Editorial Decision: Revise Minor
17 Dec 20211st Revision Received
17 Dec 2021Submission Checks Completed
17 Dec 2021Assigned to Editor
21 Dec 2021Editorial Decision: Accept
Jul 2022Published in Influenza and Other Respiratory Viruses volume 16 issue 4 on pages 789-799. 10.1111/irv.12958