Biogeochemical cycling in permafrost-affected ecosystems remains associated with large uncertainties, which could impact the Earth’s greenhouse gas budget and future climate mitigation policies. In particular, increased nutrient availability following permafrost thaw could perturb biogeochemical cycling in permafrost systems, an effect largely unexplored in global assessments. In this study, we enhance the terrestrial ecosystem model QUINCY, which fully couples carbon (C), nitrogen (N) and phosphorus (P) cycles in vegetation and soil, with processes relevant in high latitudes (e.g., soil freezing and snow dynamics). We use this enhanced model to investigate impacts of increased carbon and nutrient availability from permafrost thawing in comparison to other climate-induced effects and CO2 fertilization over 1960 to 2019 over a multitude of tundra sites. Our simulation results suggest that vegetation growth in high latitudes is acutely N-limited at our case study sites. Despite this, enhanced availability of nutrients in the deep active layer following permafrost thaw, simulated to be around 0.1 m on average since the 1960s, accounts for only 11 % of the total GPP increase averaged over all sites. Our analysis suggests that the decoupling of the timing of peak vegetative growth (week 27-29 of the year, corresponding to mid-to-late July) and maximum thaw depth (week 34-37, corresponding to mid-to-late August), lead to an incomplete plant use of newly available nutrients at the permafrost front. Due to resulting increased availability of N at the permafrost table, as well as alternating water saturation levels, increases in both nitrification and denitrification enhance N2O emissions in the simulations. Our model thus suggests a weak (5 mg N m-2 yr-1) but increasing source of N2O, which reaches trends of up to +1 mg N m-2 yr-1 per decade, locally, which is potentially of large importance for the global N2O budget.