loading page

Physiology of GPCRs in the nervous system and the contribution of orphan GPCRs
  • +16
  • Necla Birgül Iyison,
  • Clauda Abboud,
  • Dayana Abboud,
  • Abdulrasheed Abdulrahman,
  • Ana-Nicoleta Bondar,
  • Julie Dam,
  • Dogan Soner,
  • Zafiroula Georgoussi,
  • Jesus Giraldo,
  • Anemarie Horvat,
  • Christos Karoussiotis,
  • Meliha Karsak,
  • Alba Castro,
  • Miriam Scarpa,
  • Hannes Schihada,
  • Nicole Scholz,
  • Bilge Guvenc Tuna,
  • Jan Vacek,
  • Nina Vardjan
Necla Birgül Iyison
Bogazici University Faculty of Arts and Sciences

Corresponding Author:[email protected]

Author Profile
Clauda Abboud
University of Liege
Author Profile
Dayana Abboud
University of Liege
Author Profile
Abdulrasheed Abdulrahman
Author Profile
Ana-Nicoleta Bondar
Forschungszentrum Jülich GmbH
Author Profile
Julie Dam
Author Profile
Dogan Soner
Yeditepe University School of Medicine
Author Profile
Zafiroula Georgoussi
Natl Ctr Sci Res Demokritos
Author Profile
Jesus Giraldo
Universitat Autònoma de Barcelona
Author Profile
Anemarie Horvat
University of Ljubljana Faculty of Medicine
Author Profile
Christos Karoussiotis
National Centre for Scientific Research-Demokritos
Author Profile
Meliha Karsak
University of Hamburg Faculty of Medicine
Author Profile
Alba Castro
Universidade de Santiago de Compostela
Author Profile
Miriam Scarpa
Karolinska Institute Department of Clinical Neuroscience
Author Profile
Hannes Schihada
University of Marburg Faculty of Pharmacy
Author Profile
Nicole Scholz
University of Leipzig Faculty of Medicine
Author Profile
Bilge Guvenc Tuna
Yeditepe University School of Medicine
Author Profile
Jan Vacek
Palacky University Olomouc
Author Profile
Nina Vardjan
University of Ljubljana, Slovenia
Author Profile


G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important drug targets. In this review, we will first discuss the role of the nervous system GPCRs in the modulation of tripartite synapse function and how GPCRs control energy metabolism in the brain. We will then discuss the (patho)physiology and pharmacology of opioid, cannabinoid, acetylcholine, chemokine, and melatonin GPCRs in the nervous system. Furthermore, we will briefly report on adhesion GPCR function in nervous tissues. Finally, we will address orphan GPCRs, their implication in the nervous system function and disease, and the challenges that need to be addressed in the future to deorphanize them.
31 Jul 2023Submitted to British Journal of Pharmacology
01 Aug 2023Submission Checks Completed
01 Aug 2023Assigned to Editor
01 Aug 2023Reviewer(s) Assigned
20 Aug 2023Review(s) Completed, Editorial Evaluation Pending
28 Aug 2023Editorial Decision: Revise Minor
13 Feb 2024Submission Checks Completed
13 Feb 2024Assigned to Editor
22 Feb 2024Review(s) Completed, Editorial Evaluation Pending
24 Feb 2024Editorial Decision: Accept