loading page

High-resolution Multi-reflection Time-of-Flight Mass Spectrometer with Atmospheric Pressure Interface
  • +4
  • Zhengxu Huang,
  • Shuxiong Yan,
  • Yi Ren,
  • Qi Huang,
  • Yi Hong,
  • Zhengge Chen,
  • Mei Li
Zhengxu Huang
Jinan University

Corresponding Author:[email protected]

Author Profile
Shuxiong Yan
Jinan University
Author Profile
Yi Ren
Jinan University
Author Profile
Qi Huang
Jinan University
Author Profile
Yi Hong
Guangzhou Hexin Instrument Co Ltd
Author Profile
Zhengge Chen
Jinan University
Author Profile
Mei Li
Jinan University
Author Profile

Abstract

RATIONALE: Many chemical processes operate at unsteady state and require a rapid mass analysis of transients with high resolution. An atmospheric pressure interface multi-reflection time-of-flight mass spectrometer (API-MRTOF-MS) has the potential to be a powerful process analytical tool. METHODS: The ion flight path of the API-MRTOF-MS was extended from meters to over one kilometer, and the mass resolution was increased to an ultra-high level. Furthermore, the mass analysis could be done at around ten milliseconds due to the rapidity of TOFMS. The mass analyzer reflects ions via electrostatic mirrors and directs them along a folded flight path, significantly increasing flight distances and theoretically with no upper limit. The powerful API, equipped with two quadrupoles, makes the API-MRTOF-MS suitable for complex mass spectrometry methods with alternative ion selection schemes. RESULTS: A mass resolution of 116,050 for Cs + ions is achieved within a total time-of-flight of only 18 ms. An ion transmission efficiency of over 50% was achieved after 600 cycles. CONCLUSIONS: The performance of the API-MRTOF-MS demonstrates that it is exceedingly suitable for high-resolution process analysis, particularly for transient process analysis, due to its fast analysis speed and high-selectivity.
20 Jul 2023Submitted to Rapid Communications in Mass Spectrometry
20 Jul 2023Submission Checks Completed
20 Jul 2023Assigned to Editor
20 Jul 2023Review(s) Completed, Editorial Evaluation Pending
21 Jul 2023Reviewer(s) Assigned
27 Aug 2023Editorial Decision: Revise Major
03 Feb 20242nd Revision Received
04 Feb 2024Submission Checks Completed
04 Feb 2024Assigned to Editor
04 Feb 2024Review(s) Completed, Editorial Evaluation Pending
11 Feb 2024Reviewer(s) Assigned
04 Mar 2024Editorial Decision: Revise Minor
05 Mar 20243rd Revision Received
09 Mar 2024Submission Checks Completed
09 Mar 2024Assigned to Editor
09 Mar 2024Review(s) Completed, Editorial Evaluation Pending
10 Mar 2024Editorial Decision: Accept