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Upper-critical solution temperature (UCST) polymer functionalized nanomedicine for controlled drug release and hypoxia alleviation in tumor therapy
  • +4
  • Xiaoya Niu,
  • Yi Fu,
  • Lei Feng,
  • Maodi Xie,
  • Bei Li,
  • Lin Que,
  • Zhen You
Xiaoya Niu
West China Hospital of Sichuan University
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Zhen You
West China Hospital of Sichuan University

Corresponding Author:[email protected]

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Recently, nanomedicine have been successfully applied in the cancer therapy. However, how to precisely control the drug release from nanomedicine in tumor tissue and overcome the hypoxic microenvironment of tumor tissue is still an important challenge in the development of nanomedicine. In this work, a new type of drug-loaded nanoparticles P(AAm-co-AN)-AuNRs@CeO2-DOX (PA-DOX) was prepared by combining high-efficiency photothermal reagents, critical up-conversion temperature polymer layer and anti-cancer drug doxorubicin (DOX) for the treatment of liver cancer. In this system, CeO2 can decompose hydrogen peroxide to H2O2 and O2 alleviate the anaerobic microenvironment of liver cancer cells. As a photothermal reagent, AuNRs@CeO2 can convert near-infrared light into heat energy to achieve local heat to kill cancer cells and ablate solid tumors. In addition, the elevated temperature would enable the polymer layer to undergo a phase transition to release more DOX to achieve a controlled release mechanism, which will open up a new horizon for clinical cancer treatment
24 May 2023Submitted to Biotechnology Journal
27 May 2023Submission Checks Completed
27 May 2023Assigned to Editor
01 Jun 2023Reviewer(s) Assigned
25 Oct 2023Review(s) Completed, Editorial Evaluation Pending
25 Oct 2023Editorial Decision: Revise Major