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ChAdOx1 nCoV-19 vaccination generates spike-specific CD8+ T cells in aged mice
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  • William Foster,
  • Nazia Thakur,
  • Joseph Newman,
  • Alexandra Spencer,
  • Danielle Woods,
  • Leila Godfrey,
  • Sarah Ross,
  • Arianne Richard,
  • Hayley Sharpe,
  • Dalan Bailey,
  • Teresa Lambe,
  • Michelle Linterman
William Foster
Babraham Institute
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Nazia Thakur
Pirbright Institute
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Joseph Newman
Pirbright Institute
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Alexandra Spencer
University of Oxford
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Danielle Woods
University of Oxford
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Leila Godfrey
University of Oxford
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Sarah Ross
Babraham Institute
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Arianne Richard
Babraham Institute
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Hayley Sharpe
Babraham Institute
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Dalan Bailey
Pirbright Institute
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Teresa Lambe
University of Oxford
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Michelle Linterman
Babraham Institute

Corresponding Author:[email protected]

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Abstract

Effective vaccines have reduced SARS-CoV-2 morbidity and mortality; however, the elderly remain the most at risk. Understanding how vaccines generate protective immunity, and how these mechanisms change with age is key for informing future vaccine design. Cytotoxic CD8+ T cells are important for killing virally infected cells, and vaccines that induce antigen specific CD8+ T cells in addition to humoral immunity provide an extra layer of immune protection. This is particularly important in cases where antibody titres are sub-optimal, as can occur in older individuals. Here, we show that in aged mice, spike-epitope specific CD8+ T cells are generated in comparable numbers to younger animals after ChAdOx1 nCoV-19 vaccination, although phenotypic differences exist. This demonstrates that ChAdOx1 nCoV-19 elicits a good CD8+ T cell response in older bodies, but that typical age-associated features are evident on these vaccine reactive T cells.
20 Feb 2023Submitted to Immunology & Cell Biology
21 Feb 2023Submission Checks Completed
21 Feb 2023Assigned to Editor
21 Feb 2023Reviewer(s) Assigned
12 Mar 2023Review(s) Completed, Editorial Evaluation Pending
12 Mar 2023Editorial Decision: Revise Minor
20 Mar 20231st Revision Received