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Ligand regulation of the pro-inflammatory G protein-coupled receptor GPR84
  • Sara Marsango,
  • Graeme Milligan
Sara Marsango
University of Glasgow

Corresponding Author:[email protected]

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Graeme Milligan
Institute of Biomedical and Life Sciences, University of Glasgow
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GPR84 is an understudied rhodopsin-like class A G protein-coupled receptor which is arousing particular interest from a therapeutic perspective. Not least this reflects that gpr84 expression is significantly up-regulated following acute inflammatory stimuli and in inflammatory diseases and that receptor activation plays a role in regulating pro-inflammatory responses and migration of cells of the innate immune system such as neutrophils, monocytes, macrophages and microglia. Although most physiological responses of GPR84 reflect receptor coupling to Gαi/o G-proteins, several studies indicate that agonist-activated GPR84 can also recruit arrestin adaptor proteins and this regulates receptor internalisation and desensitisation. To date, very little is known on the patterns of GPR84 phosphorylation and how these might control these processes. Here, we consider what is known on the molecular basis of GPR84 signalling with a focus on how GRK-mediated phosphorylation regulates arrestin protein recruitment and receptor function.
26 Jan 2023Submitted to British Journal of Pharmacology
07 Feb 2023Submission Checks Completed
07 Feb 2023Assigned to Editor
09 Feb 2023Reviewer(s) Assigned
09 Mar 2023Review(s) Completed, Editorial Evaluation Pending
09 Mar 2023Editorial Decision: Revise Minor
06 Apr 20231st Revision Received
07 Apr 2023Submission Checks Completed
07 Apr 2023Assigned to Editor
08 Apr 2023Reviewer(s) Assigned
18 Apr 2023Review(s) Completed, Editorial Evaluation Pending
18 Apr 2023Editorial Decision: Accept