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Chronic Liver Diseases: From Development to Novel Pharmacological Therapies
  • Maria Borrello,
  • Derek Mann
Maria Borrello
University of Newcastle upon Tyne

Corresponding Author:[email protected]

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Derek Mann
University of Newcastle upon Tyne
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Chronic liver diseases comprises a broad spectrum of burdensome diseases that still lack effective pharmacological therapies. Our research group focuses on Fibrosis which is a major precursor of liver cirrhosis. Fibrosis consists in a progressive disturbance of liver sinusoidal architecture characterised by connective tissue deposition as a reparative response to tissue injury. Multifactorial events and several types of cells, participate in fibrosis initiation and progression and the process still needs to be completely understood. The development of experimental models of liver fibrosis alongside the identification of critical factors progressing fibrosis to cirrhosis will facilitate the development of more effective therapeutic approaches for such condition. This review provides an overlook of the main process leading to hepatic fibrosis and therapeutic approaches that have emerged from a deep knowledge of the molecular regulation of fibrogenesis in the liver.
16 Nov 2021Submitted to British Journal of Pharmacology
24 Nov 2021Submission Checks Completed
24 Nov 2021Assigned to Editor
25 Nov 2021Reviewer(s) Assigned
13 Dec 2021Review(s) Completed, Editorial Evaluation Pending
14 Dec 2021Editorial Decision: Revise Minor
04 Mar 20221st Revision Received
21 Mar 2022Submission Checks Completed
21 Mar 2022Assigned to Editor
23 Mar 2022Reviewer(s) Assigned
29 Mar 2022Review(s) Completed, Editorial Evaluation Pending
30 Mar 2022Editorial Decision: Accept