3.4 Prevalence of sCD25 grouping among patients according to clinical features
Grouping of CD25 levels according to the cut-off values was related to patient clinic-biological characteristics (Fig.4). High-sCD25 was more prevalent in patients younger than two years of age at diagnosis. The majority of patients with RO (liver, spleen, or hematologic) involvement had high levels of sCD25. Patients in the high-sCD25 group had more multisystem involvements and were more likely to have involvement of skin, lung, or lymph nodes. The frequency of sCD25 subgroups did not significantly differ among BRAF or MAP2K1 gene subtypes, but the high-sCD25 was closely associated with the positivity of cfBRAF -V600E in plasma.