Treatment:
In view of the recurrence of severe vaso-occlusive crises within one-year, prophylactic treatment with crizanlizumab at a dose of 5 mg/kg was started. The first loading dose was administered without complications. During the infusion of the second loading dose, he developed severe pain with a pain score of 8 out of 10, so the dose was administered over one hour instead of 30 minutes, and he required paracetamol intravenously and morphine 5 mg subcutaneously. The third dose was administered over 1 hour and subsequent doses over 30 minutes without complications.