Penicillins
Potential interactions with LAI cabotegravir/rilpivirine are expected to be minimal and of less clinical relevance except in the case of flucloxacillin. Flucloxacillin has been shown to be a moderate inducer of both CYP3A4 and UGT enzymes, an effect likely to result in increased clearance and subtherapeutic concentrations of both rilpivirine and cabotegravir. Consequently, subtherapeutic concentrations pose a risk of loss of drug effectiveness and development of resistance and co-administration is not recommended .