Quinolones
The fluoroquinolones (e.g. ciprofloxacin, ofloxacin and moxifloxacin) have long been associated with cardiotoxic adverse effects due to QT interval prolongation . Although QT prolongation is a class effect, proarrhythmic potential varies widely among individual agents, with moxifloxacin being the most likely to cause QT prolongation . The potential additive/synergistic interaction of quinolones with rilpivirine on QT interval prolongation requires caution when the drugs are to be co-administered, additional ECG monitoring may be needed with higher risk agents such as moxifloxacin.