Concomitant Medications Effects on LA CAB/RPV Clinical recommendations
Antitubercular agents Antitubercular agents Antitubercular agents
Rifampicin CAB AUC*2 Co-administration contraindicated
Rifapentine Co-administration contraindicated
Rifabutin (non-clinically significant reduction in CAB AUC) Co-administration contraindicated, due to Rilpivirine sub-therapeutic dosage; LA CAB PrEP not impacted
Isoniazid No adjustment required
Pyrazinamide No adjustment required
Ethambutol No adjustment required
Quinolones Risk of QT prolongation with both Quinolones and RPV (if present at supratherapeutic doses)
Antipsychotics and Antiepileptics Antipsychotics and Antiepileptics Antipsychotics and Antiepileptics
Carbamazepine Co-administration contraindicated
Phenytoin Co-administration contraindicated
Haloperidol Risk of QT prolongation with both Haloperidol and RPV (if present at supratherapeutic doses)
Valproate No adjustment required
Olanzapine No adjustment required
Lithium No adjustment required
SSRIs (citalopram and escitalopram) – – No adjustment required Risk of QT prolongation with both citalopram/escitalopram and RPV (if present at supratherapeutic doses)
Tricyclic antidepressants No adjustment required
Antimalarials Antimalarials Antimalarials
Artemisinin Co-administration contraindicated due to Rilpivirine sub-therapeutic dosage; LA CAB PrEP not impacted
Lumefantrine Risk of QT prolongation with both Haloperidol and RPV (if present at supratherapeutic doses)
Atovaquone/proguanil No adjustment required
Primaquine Risk of QT prolongation with both Haloperidol and RPV (if present at supratherapeutic doses)
Quinine Risk of QT prolongation with both Haloperidol and RPV (if present at supratherapeutic doses)
Antibacterials Antibacterials Antibacterials
Penicillins (Flucloxacillin) – CAB↓ RPV↓ No adjustments required Co-administration contraindicated
Metronidazole Potential RPV ↑ Risk of QT prolongation with both metronidazole and RPV (if present at supratherapeutic doses)
Fluoroquinolones Risk of QT prolongation with both fluoroquinolones, especially moxifloxacin and RPV (if present at supratherapeutic doses)
Macrolides (Azithromycin) RPV ↑ – Risk of QT prolongation with both Macrolides and RPV (if present at supratherapeutic doses) No adjustments with azithromycin
Gentamicin No adjustment required
Cephalosporins No adjustment required
Carbapenem No adjustment required
Antifungals Antifungals Antifungals
Azoles Monitor for QT prolongation
Amphotericin No adjustment required
Griseofulvin Co-administration contraindicated
Contraceptives
Combined oral No adjustment required
DMPA No adjustment required
Levonorgestrel implant No adjustment required