Penicillins
Potential interactions with LAI cabotegravir/rilpivirine are expected to
be minimal and of less clinical relevance except in the case of
flucloxacillin. Flucloxacillin has been shown to be a moderate inducer
of both CYP3A4 and UGT enzymes, an effect likely to result in increased
clearance and subtherapeutic concentrations of both rilpivirine and
cabotegravir. Consequently, subtherapeutic concentrations pose a risk of
loss of drug effectiveness and development of resistance and
co-administration is not recommended .