Quinolones
The fluoroquinolones (e.g. ciprofloxacin, ofloxacin and moxifloxacin)
have long been associated with cardiotoxic adverse effects due to QT
interval prolongation . Although QT prolongation is a class effect,
proarrhythmic potential varies widely among individual agents, with
moxifloxacin being the most likely to cause QT prolongation . The
potential additive/synergistic interaction of quinolones with
rilpivirine on QT interval prolongation requires caution when the drugs
are to be co-administered, additional ECG monitoring may be needed with
higher risk agents such as moxifloxacin.