Concomitant Medications |
Effects on LA CAB/RPV |
Clinical recommendations |
Antitubercular agents |
Antitubercular
agents |
Antitubercular agents |
Rifampicin |
CAB AUC*2
|
Co-administration
contraindicated |
Rifapentine |
|
Co-administration
contraindicated |
Rifabutin |
(non-clinically significant reduction in CAB AUC) |
Co-administration contraindicated, due to Rilpivirine
sub-therapeutic dosage; LA CAB PrEP not impacted |
Isoniazid |
– |
No adjustment required |
Pyrazinamide |
– |
No adjustment required |
Ethambutol |
– |
No adjustment required |
Quinolones |
– |
Risk of QT prolongation with both Quinolones and RPV
(if present at supratherapeutic doses) |
Antipsychotics and Antiepileptics |
Antipsychotics and Antiepileptics |
Antipsychotics and Antiepileptics |
Carbamazepine |
|
Co-administration
contraindicated |
Phenytoin |
|
Co-administration contraindicated |
Haloperidol |
– |
Risk of QT prolongation with both Haloperidol and
RPV (if present at supratherapeutic doses) |
Valproate |
– |
No adjustment required |
Olanzapine |
– |
No adjustment required |
Lithium |
– |
No adjustment required |
SSRIs
(citalopram and escitalopram)
|
–
–
|
No adjustment required
Risk of QT prolongation with both citalopram/escitalopram and RPV (if
present at supratherapeutic doses)
|
Tricyclic antidepressants |
– |
No adjustment required |
Antimalarials |
Antimalarials |
Antimalarials |
Artemisinin |
|
Co-administration contraindicated due to
Rilpivirine sub-therapeutic dosage; LA CAB PrEP not
impacted |
Lumefantrine |
– |
Risk of QT prolongation with both Haloperidol and
RPV (if present at supratherapeutic doses) |
Atovaquone/proguanil |
– |
No adjustment required |
Primaquine |
– |
Risk of QT prolongation with both Haloperidol and
RPV (if present at supratherapeutic doses) |
Quinine |
– |
Risk of QT prolongation with both Haloperidol and RPV
(if present at supratherapeutic doses) |
Antibacterials |
Antibacterials |
Antibacterials |
Penicillins
(Flucloxacillin)
|
–
CAB↓ RPV↓
|
No adjustments required
Co-administration contraindicated
|
Metronidazole |
Potential RPV ↑ |
Risk of QT prolongation with both
metronidazole and RPV (if present at supratherapeutic
doses) |
Fluoroquinolones |
– |
Risk of QT prolongation with both
fluoroquinolones, especially moxifloxacin and RPV (if present at
supratherapeutic doses) |
Macrolides
(Azithromycin)
|
RPV ↑
–
|
Risk of QT prolongation with both Macrolides and RPV (if present at
supratherapeutic doses)
No adjustments with azithromycin
|
Gentamicin |
– |
No adjustment required |
Cephalosporins |
– |
No adjustment required |
Carbapenem |
– |
No adjustment required |
Antifungals |
Antifungals |
Antifungals |
Azoles |
|
Monitor for QT prolongation |
Amphotericin |
– |
No adjustment required |
Griseofulvin |
|
Co-administration
contraindicated |
Contraceptives |
|
|
Combined oral |
– |
No adjustment required |
DMPA |
– |
No adjustment required |
Levonorgestrel implant |
– |
No adjustment required |