Metronidazole
Metronidazole is thought to inhibit CYP3A4 ; however, co-administration
with several CYP3A4 probes (e.g. midazolam) did not result in increased
plasma concentrations of these substrates . Considering that the precise
mechanism of metronidazole inhibition of CYP450 enzyme machinery is yet
to be fully elucidated, an interaction with rilpivirine cannot be ruled
out . More data is required on metronidazole’s CYP3A4 inhibitory
effects.
There are no anticipated interactions with cephalosporins, carbapenems
and aminoglycosides such as gentamicin.