Metronidazole
Metronidazole is thought to inhibit CYP3A4 ; however, co-administration with several CYP3A4 probes (e.g. midazolam) did not result in increased plasma concentrations of these substrates . Considering that the precise mechanism of metronidazole inhibition of CYP450 enzyme machinery is yet to be fully elucidated, an interaction with rilpivirine cannot be ruled out . More data is required on metronidazole’s CYP3A4 inhibitory effects.
There are no anticipated interactions with cephalosporins, carbapenems and aminoglycosides such as gentamicin.