Study population
We included finalized multicentre RCTs supported by the clinical trial centre and performed within the Dutch Consortium for Women’s Health Research, between March 1st 2003 and December 1st 2023. We excluded studies with an observational design, single centre RCTs, RCTs initiated outside the Netherlands, RCTs with a cluster or parallel study design, RCTs that never actually started, RCTs in which inclusion of patients was still ongoing and RCTs prematurely discontinued for other reasons than poor recruitment, for example due to safety issues after an interim analysis.