An asymmetric isomerization/intramolecular coupling reaction of allylic
alcohols to synthesize chiral dihydrocoumarins was successfully
accomplished through ruthenium catalysis. This method demonstrates a
wide substrate applicability, excellent tolerance for various functional
groups, and good enantioselectivities (up to 90% ee). It provides a
convenient pathway to produce a diverse range of structurally distinct
chiral dihydrocoumarins in good efficiency.
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