entry |
ligand |
base |
solvent |
yield (%) |
ee (%) |
1 |
L1 |
TMP |
toluene |
83 |
14 |
2 |
L2 |
TMP |
toluene |
58 |
78 |
3 |
L3 |
TMP |
toluene |
67 |
68 |
4 |
L4 |
TMP |
toluene |
70 |
13 |
5 |
L5 |
TMP |
toluene |
26 |
13 |
6 |
L6 |
TMP |
toluene |
7 |
3 |
7 |
L7 |
TMP |
toluene |
52 |
2 |
8 |
L8 |
TMP |
toluene |
72 |
21 |
9 |
L9 |
TMP |
toluene |
62 |
69 |
10 |
L2 |
K2CO3
|
toluene |
75 |
83 |
11 |
L2 |
DBU |
toluene |
77 |
39 |
12 |
L2 |
K2CO3
|
DCE |
78 |
89 |
13 |
L2 |
K2CO3
|
Ph-CF3
|
72 |
87 |