Ruthenium-Catalysed Asymmetric Intramolecular Isomerization/Esterification Reaction: Direct Synthesis of Chiral Dihydrocoumarins Lingzi Zhao,a,‡ Xuchao Wang,a,‡ Qing Qiang,a Xingwei Zhao,b Feipeng Liu,*,a Shenci Lu,*,a and Zi-Qiang Rong *,a Chin. J. Chem. 2024, 42, XXX—XXX. DOI: 10.1002/cjoc.202300XXX
Herein, an asymmetric isomerization/intramolecular coupling reaction of allylic alcohols to synthesize chiral dihydrocoumarins was successfully accomplished through ruthenium catalysis. This method demonstrates a wide substrate applicability, excellent tolerance for various functional groups, and good enantioselectivities (up to 90% ee). It provides a convenient pathway to produce a diverse range of structurally distinct chiral dihydrocoumarins in good efficiency.