IgE quantification
Patients’ sera were applied individually to the research version of the ALEX2Allergy Explorer (MacroArray Diagnostics). Total and allergen-specific IgE were quantified as described previously.16 Values above 0.3 kU/L were considered positive.
Statistical analysis
The statistical analyses were performed using GraphPad Prism 9 (San Diego, CA), IBM SPSS Statistics 26 (Armonk, NY), R programming language and RStudio (Boston, MA), as explained in supplementary material.