Use of non-standard antibiotic regimens
The overall use of non-standard antibiotic regimens was not significantly different after the intervention (11.9% before versus 12.7% after). However, it was significantly more frequent in PHO units located in general versus pediatric hospitals prior to intervention (p =0.001) and remained so post-intervention (p =0.001). Triple antibiotic therapy decreased in units 1 and 2, monotherapy with an antipseudomonal beta-lactam decreased in the BMT unit, and triple antibiotic therapy and non-standard antibiotic combinations decreased in unit 6.