PHIG intervention
The surveillance of antibiotic use and the educational intervention about the implementation of the CPG started in December 2017 for five of the units; one started in March 2018 due to local resource restrictions, while one of the units participated in data collection only during the pre-intervention period (June 2016 to December 2017) due to limited resources. The same demographic and clinical data were recorded in the post-intervention two-year period (January 2018 to December 2019), to compare antimicrobial use before and after implementation of the guidelines for the management of FN in children with cancer and HSCT recipients.13