Abstract
Objective: Covid-19 may cause thrombosis in both venous and
arterial systems. Familiarity with the signs and symptoms of thrombosis
and their treatment plays an important role in treating Covid-19
infection and its complications. D-Dimer and Mean platelet volume (MPV)
are measurements related to the development of thrombosis. This study
investigates whether MPV and D-Dimer values could be used to determine
the risk of thrombosis and mortality in Covid-19 early stages.
Methods : 424 patients were randomly and retrospectively
included in the study, Covid 19 positive according to the World Health
Organization (WHO) guidelines. Demographic and clinical characteristics
such as age, gender, and length of hospitalization were obtained from
the digital records of participants. Participants were divided into
living and deceased groups.
Results: WBC, neutrophils, and monocytes were significantly
different in the two groups (p <0.001), and its values were
lower in the living group than in the deceased group. MPV median values
do not differ according to prognosis (p = 0.994). Creatinine,
Procalcitonin, Ferritin, and the number of hospitalization days in
living patients were significantly lower than in patients who died (p
<0.001). Median values of D-dimer (mg / L) differ according to
prognosis (p <0.001). While the median value was 0.63 in the
survivors, it was found as 4.38 in the deceased.
Conclusion: Our results did not show any significant
relationship between the mortality of Covid-19 patients and their MPV
levels. However, a significant association of D-Dimer and mortality in
Covid-19 patients was observed.
Keywords: COVID-19, MPV, D-Dimer, prognosis, mortality