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\begin{document}

\title{The Interleukin 6 (IL-6) blockade for coronavirus disease 2019
(COVID-19) In Lung}



\author[1]{Zhili Rao}%
\author[2]{Hongli Zhou}%
\author[1]{Xiangyu Li}%
\author[3]{Nan Zeng}%
\affil[1]{Department of Pharmacology, College of Pharmacy, Chengdu University of Traditional Chinese Medicine,Chengdu city, Sichuan Province, Chengdu 611137, PR China}%
\affil[2]{National Drug Clinical Trial Institution, the Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.}%
\affil[3]{Chengdu University of Traditional Chinese Medicine}%


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  \date{May 16, 2024}


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\begin{abstract}
COVID-19 has caused global pandemics since the emergent outbreak and
resulted in a large number of deaths. IL-6, as an important autoimmune
cytokine, had been suggested for the treatment of acute respiratory
distress syndrome (ARDS) patients in COVID-19. A review of the relevant
literature revealed more than one role for IL-6 in the lung infection
because of its diverse biological effects. It may have a variety of
different physiological functions in the development of lung infection.
We have summarized its role in different progress of COVID-19, including
lung infection, pneumonia, ALI, pulmonary fibrosis, and lung translation
and even lung cancer. This will facilitate a deeper understanding of the
role of IL-6 in the treatment of COVID-19.%
\end{abstract}%



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