Impact of Current Enuresis on long term outcomes:
We performed repeated data analysis to determine the impact of currently
having enuresis on longitudinal kidney outcomes using a GEE approach. In
a univariate analysis, children with current enuresis had increased odds
of having sickle cell anemia (OR: 2.33 95% CI: 1.02-5.34, p=0.045).
Children with current enuresis were identified with higher odds of
having higher eGFR values (OR 1.07, CI 1.1-1.12, p=0.014) and
categorized as having hyperfiltration (OR 1.01, CI 1.0-1.02, p=0.038)
(Figure 2) when adjusted for age and sex in the model. When SCD type was
added to the model of age and sex, the association between current
enuresis and either eGFR or hyperfiltration (eGFR: OR: 1.05, 95% CI:
0.99-1.10, p=0.085; hyperfiltration: OR: 1.01, 95%CI: 1.00-1.02,
p=0.11) was no longer statistically
significant. Children with current
enuresis maintained an average lower hemoglobin and an average higher
LDH over time (OR: 0.92, CI: 0.85-0.98, p=0.016 and OR 1.03, CI:
1.01-1.06, p=0.0017), which remained significant after adjusting for age
and sex (OR:0.91, CI: 0.84-0.99, p=0.027 and OR 1.03, CI:1.01-1.06,
p=0.0048, respectively). Again, when including SCD type in the GEE
model, this association was no longer significant.