Conclusion:
The current study identifies elevated level of IL-6, higher percentage
of CD14+CD16+ inflammatory large monocytes and lower percentage of
circulating naïve (CD27+CD28+CD45RA+CCR7+) CD4+ T cells early in the
disease course as independent early predictors of ICU admission or death
in patients with COVID-19 infection. Such predictors can be used for
early identification of patients who might deteriorate and thus need
early aggressive interventions. Larger studies are required to validate
the current findings aiming toward better early clinical management.