Conclusion
We demonstrated that exposure to 60 ng/m3 of Bet v 1 in the ALYATEC EEC induces conjunctival responses in more than 50% of patients with birch allergic conjunctivitis. Birch allergen exposures inducing early conjunctival responses were different than those identified with direct instillation during CAC, demonstrating that EECs more closely mimic a natural exposure during high pollinating days.