CD45 |
Surface |
Leukocytes (excludes erythrocytes and platelets) |
|
CD3 |
Surface |
T lymphocytes |
|
CD4/CD8 |
Surface |
Helper T cells/Cytotoxic T cells |
|
CD45RA |
Surface |
High expression identifies naive T cells |
(31,64) |
CD27 |
Surface |
Highly expressed in naïve T cells but lost in fully
differentiated cells after persistent antigen stimulation |
(31) |
Integrin β7 (β7) |
Surface |
Gut-homing marker. |
(32) |
CD161 |
Surface |
Type 17 responses and cytotoxic functions. |
(58,65) |
PSGL-1 (CLA) |
Surface |
Skin-homing marker. |
(66) |
CXCR-5 |
Surface |
Follicular T cell marker. |
(67) |
LAG-3 |
Surface |
Inhibitory receptor upregulated in recently activated
lymphocytes. |
(68) |
FcERI (FCER1A) |
Surface |
High affinity receptor for IgE. |
(69) |
CD49b |
Surface |
Integrin (α2β1) that binds to collagen and modulates T
cell stimulation, cytokine production and survival. |
(70,71) |
CD137 |
Surface |
Costimulatory receptor, promoting proliferation and
survival, upregulated in activated lymphocytes. |
(72) |
CRTH2 |
Surface |
Type 2 responses. |
(73) |
CD40L |
Surface |
Costimulatory ligand expressed on activated T cells. |
(74) |
T-box protein 21
(T-bet)
|
Intracellular
|
Type 1 responses and effector CD8+ cells
differentiation
|
(75)
|
GATA-3 |
Intracellular |
Type 2 responses and cytotoxic
CD8+ function |
(76) |
BCL-6 |
Intracellular |
Involved in follicular helper T cell
differentiation. Involved in granzyme B production and memory
differentiation in CD8+ T cells. |
(77,78) |
Forkhead box protein P3 (FoxP3) |
Intracellular |
Transcription factor
expressed by regulatory T cells. |
(79) |
Nur77 |
Intracellular |
Transcription factor indicative of T cell
activation. |
(80) |