Author Contributions
J.G.A.R. and D.N. together carried out all the analyses, participated in the project design and wrote the manuscript. B.S-N and G.V.P. performed the flow cytometry experiments. L.K., T.M.A., F.M-W., A.G.S., C.L.W. and J.T. provided intellectual input with the data analysis. P.H., N.J.C.K., and L.M. helped with the study design. R.N. designed the project, supervised the study, and wrote the manuscript. All authors reviewed and edited the manuscript.