A Gap of Knowledge:
Despite numerous studies on COVID-19, no gold-standard treatment for this disease has been found yet, hence the current use of supportive therapies. The best way to manage the disease is through prevention, with vaccination already underway around the world; nonetheless, many cases of COVID-19–related infection and death are still reported.
Most COVID-19 supportive drugs modulate the immune system to regulate inflammatory storms (5). Many of the immune modulators have immunosuppressive properties that may not work properly in viral disorders (5). NAC is one of the few immune modulators without immunosuppressive properties (31). However, all the articles suggesting the use of NAC in the treatment of COVID-19 recommend further well-designed randomized controlled clinical trials (RCTs).