A Gap of Knowledge:
Despite numerous studies on COVID-19, no gold-standard treatment for
this disease has been found yet, hence the current use of supportive
therapies. The best way to manage the disease is through prevention,
with vaccination already underway around the world; nonetheless, many
cases of COVID-19–related infection and death are still reported.
Most COVID-19 supportive drugs modulate the immune system to regulate
inflammatory storms (5). Many of the immune modulators have
immunosuppressive properties that may not work properly in viral
disorders (5). NAC is one of the few immune modulators without
immunosuppressive properties (31). However, all the articles suggesting
the use of NAC in the treatment of COVID-19 recommend further
well-designed randomized controlled clinical trials (RCTs).