Figure 2 . HA-specific IgG and Omicron BA.5 S-RBD-specific IgG detection in immunized mouse sera. (A) HA-specific IgG antibody titers in the serum of mice in each group on days 21 and 35 antibody titers; (B) Omicron BA.5 S-RBD-specific IgG in serum of mice in each group on days 21 and 35 antibody titers. (C) Curve of HA-specific IgG in immunized mice on day 35. (D) Curve of Omicron BA.5 S-RBD-specific IgG in immunized mice on day 35. Geometric mean was calculated for each set of data, as shown, and compared. Statistical significance was determined by two-way ANOVA and is indicated as follows: ** p < 0.01, *** p < 0.001,**** p < 0.0001. Error bars represent SD.
3.2