Methods
All experiments with human samples were conducted according to approval of the local ethics committee of Rhineland Palatinate (authorization no. 837.303.13 and 837.054.17 (10888)) and written informed consent was obtained from all participants. Murine experiments were in accordance with current federal, state, and institutional guidelines (authorisation no. 23 177-07/G 18-1-015).
Methods are described in brief, for further details see Supplementary Methods.