Figure legends
FIGURE 1 (A) Cystic lesion in right kidney observed by ultrasonography performed at 25, 31, and 35 weeks of gestation. Diameters of cystic lesion indicated by arrowheads and dotted lines are shown in lower right panel. (B) Histopathological findings of osteoblast-like cells with ossification (*) and proliferated spindle cells (+) in the tumor tissue.
FIGURE 2 (A) Tumor-specific heterozygous c.121A>G (p.T41A) mutation of the CTNNB1 gene in Sanger sequencing of genomic PCR products. Lower panel indicates hotspot mutations downloaded from the MSK-IMPACT pan-cancer study on cBioportal. (B) Nuclear accumulations of β-catenin protein, encoded by CTNNB1 , in osteoblast-like cells (left) and spindle cells (right) of the tumor tissue by immunohistochemistry. (C) Schematic representation of three types of childhood benign tumors with CTNNB1 mutations characterized by nested proliferation of spindled and epithelioid cells with calcification or ossification including ossifying renal tumor of infancy (ORTI) as well as previously described pilomatricoma and calcifying nested stromal-epithelial tumor (CNSET). Illustration was created with BioRender.com.