Figure legends
FIGURE 1 (A) Cystic lesion in right kidney observed by
ultrasonography performed at 25, 31, and 35 weeks of gestation.
Diameters of cystic lesion indicated by arrowheads and dotted lines are
shown in lower right panel. (B) Histopathological findings of
osteoblast-like cells with ossification (*) and proliferated spindle
cells (+) in the tumor tissue.
FIGURE 2 (A) Tumor-specific heterozygous c.121A>G
(p.T41A) mutation of the CTNNB1 gene in Sanger sequencing of
genomic PCR products. Lower panel indicates hotspot mutations downloaded
from the MSK-IMPACT pan-cancer study on cBioportal. (B) Nuclear
accumulations of β-catenin protein, encoded by CTNNB1 , in
osteoblast-like cells (left) and spindle cells (right) of the tumor
tissue by immunohistochemistry. (C) Schematic representation of three
types of childhood benign tumors with CTNNB1 mutations
characterized by nested proliferation of spindled and epithelioid cells
with calcification or ossification including ossifying renal tumor of
infancy (ORTI) as well as previously described pilomatricoma and
calcifying nested stromal-epithelial tumor (CNSET). Illustration was
created with BioRender.com.