Figure 5: Mechanism investigation of PFD and BIBF against
silicosis was indicated by metabolomics. (A) Heatmap of differential
metabolites between PBS group (n=5) and Si group (n=5). (B)KEGG pathway analysis of differential metabolites between PBS group and
Si group. (C) Heatmap of differential metabolites between Si
group (n=5) and PFD group (n=5). (D) KEGG pathway analysis of
differential metabolites between Si group and PFD group. (E)Heatmap of differential metabolites between Si group (n=5) and BIBF
group (n=5). (F) KEGG pathway analysis of differential
metabolites between Si group and BIBF group. (G) Venn diagram
showing the overlapping pathways among three comparisons, including PBS
vs Si, Si vs PFD, and Si vs BIBF. (H) Bubble plot of
multi-class KEGG pathway enrichment analysis in Figure 5G. The
highlighted pathways refer to the intersection of three comparisons.