Figure 4: Transcriptomic analysis revealed distinct and shared
mechanisms underlying PFD and BIBF treating silicosis. (A) Flowchart of
mechanism exploration by transcriptomic and metabolomic analysis.(B) Heatmap of DEGs (P -values< 0.05) between
PBS group (n=5) and Si group (n=6). (C) Volcano plot
representing the analysis of DEGs between PBS group and Si group. KEGG
pathway analysis of downregulated DEGs (D) and upregulated DEGs(E) between PBS group and Si group. (F) Heatmap of
DEGs between Si (n=6) group and PFD group (n=7). (G) Volcano
plot of DEGs between Si group and PFD group. (H) KEGG pathway
analysis of DEGs between Si group and PFD group. (I) Heatmap of
DEGs between Si group (n=6) and BIBF group (n=4). (J) Volcano
plot of DEGs between Si group and BIBF group. (K) KEGG pathway
analysis of DEGs between Si group and BIBF group. (L)Venn diagram showing the
overlapping pathways among three comparisons, including PBS vs Si, Si vs
PFD, and Si vs BIBF. (M) Bubble plot of multi-class KEGG
pathway enrichment analysis in Figure 4L.