Author Contributions
Chen Wang and Jing Wang conceived the idea and supervised the whole
project. Meiyue Song contributed to the study design, participated in
carrying out animal experiments, and revised the manuscript. Lu Bai and
Xue Wang conducted animal experiments and contributed to data collection
and analysis. Jiaxin Wang drafted and edited the article and
participated the data analysis. Wei Zeng assisted with histological and
molecular experiments. Jixin Wang and Junling Pang performed the RNA-seq
analysis. Shengxi Li provided technical assistance with the metabolomics
detection. Tiantian Zhang assisted with the data review and manuscript
revision. The manuscript was approved by all authors.