LEGENDS
FIGURE 1 Percent of patients that received 23.4 Gray
(A ) or 36-39.6 Gray (B ) craniospinal irradiation who
developed grades 2-4 lymphopenia during radiation therapy
FIGURE 2 Absolute lymphocyte count during radiation therapy in
patients that received 23.4 Gray (A ) or 36-39.6 Gray
craniospinal irradiation (B )
FIGURE 3 Higher risk of disease recurrence (lower
recurrence-free survival) with grade 3 or 4 lymphopenia in weeks 4
(A ) and 5 (B ) radiation therapy (log-rank p=0.015 and
Cox p=0.03 for week 4; log-rank p=0.0009 and Cox p=0.004 for week 5)
FIGURE 4 Low absolute lymphocyte count (ALC) during week 5 of
radiation therapy is associated with lower recurrence-free survival
(higher risk of disease recurrence) (B ); this association was
significant during week 4 of radiation (A ) (log-rank p=0.123
and Cox p=0.22 for week 4; log-rank p=0.0026 and Cox p=0.002 for week 5)
(*low/high split on median ALC value of 0.4368 for week 4 and 0.4905 for
week 5)
SUPPLEMENTAL FIGURE 1 No difference between recurrence-free
survival in patients treated with proton vs. photon radiation therapy
(hazard ratio=0.40, p=0.09)