LEGENDS
FIGURE 1 Percent of patients that received 23.4 Gray (A ) or 36-39.6 Gray (B ) craniospinal irradiation who developed grades 2-4 lymphopenia during radiation therapy
FIGURE 2 Absolute lymphocyte count during radiation therapy in patients that received 23.4 Gray (A ) or 36-39.6 Gray craniospinal irradiation (B )
FIGURE 3 Higher risk of disease recurrence (lower recurrence-free survival) with grade 3 or 4 lymphopenia in weeks 4 (A ) and 5 (B ) radiation therapy (log-rank p=0.015 and Cox p=0.03 for week 4; log-rank p=0.0009 and Cox p=0.004 for week 5)
FIGURE 4 Low absolute lymphocyte count (ALC) during week 5 of radiation therapy is associated with lower recurrence-free survival (higher risk of disease recurrence) (B ); this association was significant during week 4 of radiation (A ) (log-rank p=0.123 and Cox p=0.22 for week 4; log-rank p=0.0026 and Cox p=0.002 for week 5) (*low/high split on median ALC value of 0.4368 for week 4 and 0.4905 for week 5)
SUPPLEMENTAL FIGURE 1 No difference between recurrence-free survival in patients treated with proton vs. photon radiation therapy (hazard ratio=0.40, p=0.09)