OUTCOME EFFECT SIZE (RR OR WMD) 95% CI p-VALUE
Total adverse events (induction) 0.4mg ciprofol 0.5 mg ciprofol RR: 0.76 0.93 0.61 0.46,1.25 0.85,1.01 0.49,1.25 0.28 0.10 <0.0001
Tachycardia 0.4mg cipro vs propo (induction) 0.5mg cipro vs propo (induction) o.4mg ciprofol (induction and maintenance) RR: 0.24 0.24 3.00 0.03 0.0040.04,1.51 0.04,1.45 0.12,72.29 0.00,0.45 0.13 0.12 0.50 0.01
Rash 0.4mg cipro vs propo (induction) 0.4mg ciprofol (induction and maintenance) RR: 1.33 1.48 1.26 0.22,8.25 0.06,35.64 0.14,11.68 0.76 0.81 0.84
Prolonged QT interval RR: 0.43 0.05,3.95 0.45
Pain on injection site (induction) 0.4mg ciprofol 0.5mg ciprofol RR: 0.16 0.26 0.02 0.06,0.44 0.13,0.52 0.00,0.14 0.0003 0.09 <0.0001
Hypoxia 0.4mg cipro vs propo (induction) 0.4mg cipro vs propo (indcution and maintenance) RR: 1.56 1.80 1.06 0.31,7.94 0.27,12.09 0.05,24.25 0.59 0.55 0.97
Hypotension 0.4mg cipro vs propo (induction) 0.5mg cipro vs propo (induction) 0.4mg (induction and maintenance) RR: 0.74 0.67 0.69 0.71 0.53,1.02 0.35,1.29 0.48,1.01 0.35,1.46 0.06 0.23 0.06 0.35
Hypertension (induction) 0.4mg cipro vs propo 0.5mg cipro vs propo RR: 1.61 1.36 2.00 0.54,4.86 0.31,5.95 0.38,10.54 0.39 0.68 0.41
CTCAE Severity Grading (grade 1) 0.4mg cipro vs propo (induction) 0.mg cipro vs propo (induction and maintenance) RR: 1.21 1.37 1.00 0.89 1.10,1.70 0.70,1.43 0.23 0.005 1.00
CTCAE Severity Grading (Grade 2) 0.4mg cipro vs propo (induction) 0.4mg cipro vs propo (induction and maintenance) RR: 0.95 0.94 0.96 0.80,1.14 0.73,1.22 0.75,1.24 0.60 0.65 0.77
Bradycardia 0.4mg cipro vs propo (induction) 0.5mg cipro vs propo (induction) 0.4mg cipro vs propo (induction and maintenance) RR: 0.81 0.89 1.17 0.74 0.58,1.14 0.47,1,70 0.41,3.28 0.45,1.22 0.23 0.72 0.77 0.24
Any treatment-emergent adverse events 0.4mg cipro vs propo (induction) 0.4mg cipro vs propo (induction and maintenance) RR: 1.07 1.05 1.14 0.96,1.19 0.94,1.19 0.90,1.45 0.21 0.38 0.29
0.4 mg Number of patients who maintained BIS between at 40 - 60 (min) RR: 1.31 0.59,2.90 0.51
0.4 mg elevated AST (induction and Maintenance) RR: 0.69 0.09,5.40 0.72