Methods
Data Sources and Search StrategyCochrane and Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines were implemented while executing and publishing this meta-analysis.[11] A comprehensive electronic search performed using Medline, Google Scholar, Embase, and Cochrane Central was conducted to identify relevant randomized controlled trials (RCTs). The search strategy was composed of the following keywords and their MeSH terms ”Propofol” OR ”2,6-Diisopropylphenol” OR ”2,6 Diisopropylphenol” OR ”2,6-Bis(1-methyl ethyl)phenol” OR ”Disoprofol” OR ”Diprivan” OR ”Disoprivan” OR ”Fresofol” OR ”ICI-35,868” OR ”ICI 35,868” OR ”ICI35,868” OR ”ICI-35868” OR ”ICI 35868” OR ”ICI35868” OR ”Ivofol” OR ”Propofol Fresenius” OR ”Propofol MCT” OR ”Propofol Rovi” OR ”Propofol-Lipuro” OR ”Recofol” OR ”Aquafol” OR ”Propofol Abbott” AND ”ciprofol OR HSK3486” AND ”anesthesia OR sedation”. The PRISMA diagram of the studies used can be found in the PRISMA flow chart in the supplementary material. Figure 1. Information about the search strategy is given in supplementary table 1.Eligibility CriteriaThe study selection process was conducted in accordance with predetermined eligibility criteria and specific outcome measures. Only double-arm, randomized controlled trials (RCTs) were included in our analysis. The target demographic compromised individuals aged eighteen or over. The intervention involved utilization of ciprofol which was compared with the administration of propofol. The primary outcome assessed was the induction and maintenance of general anesthesia. Some studies were omitted based on the exclusion criteria. Studies in which ciprofol was utilized for screening and diagnostic procedures were not included. Articles published in languages other than English or any other specified language were excluded from consideration. Furthermore, all types of reviews (systematic and non-systematic), case reports, case series, cross-sectional, editorials, commentaries, and animal studies were excluded to maintain the integrity and focus of our study. This rigorous selection process aimed to ensure the quality and relevance of the studies included in our systematic review and meta-analysis.