Data Sources and Search StrategyCochrane and Preferred Reporting Items for Systematic Review and
Meta-Analyses (PRISMA) guidelines were implemented while executing and
publishing this meta-analysis.[11] A comprehensive electronic search
performed using Medline, Google Scholar, Embase, and Cochrane Central
was conducted to identify relevant randomized controlled trials (RCTs).
The search strategy was composed of the following keywords and their
MeSH terms ”Propofol” OR ”2,6-Diisopropylphenol” OR ”2,6
Diisopropylphenol” OR ”2,6-Bis(1-methyl ethyl)phenol” OR ”Disoprofol” OR
”Diprivan” OR ”Disoprivan” OR ”Fresofol” OR ”ICI-35,868” OR ”ICI 35,868”
OR ”ICI35,868” OR ”ICI-35868” OR ”ICI 35868” OR ”ICI35868” OR ”Ivofol”
OR ”Propofol Fresenius” OR ”Propofol MCT” OR ”Propofol Rovi” OR
”Propofol-Lipuro” OR ”Recofol” OR ”Aquafol” OR ”Propofol Abbott” AND
”ciprofol OR HSK3486” AND ”anesthesia OR sedation”. The PRISMA diagram
of the studies used can be found in the PRISMA flow chart in the
supplementary material. Figure 1. Information about the search
strategy is given in supplementary table 1.Eligibility CriteriaThe study selection process was conducted in accordance with
predetermined eligibility criteria and specific outcome measures. Only
double-arm, randomized controlled trials (RCTs) were included in our
analysis. The target demographic compromised individuals aged eighteen
or over. The intervention involved utilization of ciprofol which was
compared with the administration of propofol. The primary outcome
assessed was the induction and maintenance of general anesthesia. Some
studies were omitted based on the exclusion criteria. Studies in which
ciprofol was utilized for screening and diagnostic procedures were not
included. Articles published in languages other than English or any
other specified language were excluded from consideration. Furthermore,
all types of reviews (systematic and non-systematic), case reports, case
series, cross-sectional, editorials, commentaries, and animal studies
were excluded to maintain the integrity and focus of our study. This
rigorous selection process aimed to ensure the quality and relevance of
the studies included in our systematic review and meta-analysis.