6.1.5 Treatment setting
There is a large variation across the existing studies for psychedelics
for OUD studies in regard to treatment settings. For example, the early
LSD studies were mostly carried out in residential settings, the study
investigating ayahuasca was completed in a retreat setting, and many of
the trials with ibogaine or noribogaine were carried out in various
medical treatment centers. Pain studies have traditionally occurred in
two settings: (1) human laboratory investigations and (2) real-word,
ambulatory and emergency room studies. Treatment setting determination
may also be influenced by which phase of treatment is being targeted
(i.e., acute withdrawal) or by other safety concerns that may require
continuous medical monitoring. Treatment setting is overall an important
consideration for research design but also for real-world implementation
if such psychedelic treatments receive regulatory approval.