Prednisolone
The mean ± SD of Cmax and AUC0-t of oral
prednisolone before repeated administration of carotegrast methyl (day
-1) was 156.1 ± 28.7 ng mL-1 and 571.6 ± 98.1 ng h
mL-1, respectively. The Cmax and
AUC0-t of prednisolone after 14-day administration of
carotegrast methyl (day 14) was 138.0 ± 19.7 ng mL-1and 631.0 ± 77.9 ng h mL-1, respectively. The
geometric mean ratio of the Cmax and
AUC0-t of prednisolone on day 14 to those on day -1 was
0.89 (90% CI, 0.84 – 0.95) and 1.11 (90% CI, 1.08 – 1.15),
respectively, which fell within the range of 0.80 – 1.25, suggesting
that carotegrast methyl had no pharmacokinetic interaction with oral
prednisolone. The Cmax and AUC0-t of
prednisolone 14 days after the end of carotegrast methyl administration
(day 28) was 150.0 ± 28.6 ng mL-1 and 571.9 ± 96.5 ng
h mL-1, respectively. The geometric mean ratio of the
Cmax and AUC0-t of prednisolone on day
28 to those on day -1 was 0.96 (90% CI, 0.91 – 1.02) and 1.00 (90%
CI, 0.97 – 1.04), respectively.