CONCLUSION
In the context of severe headache not subsiding with conservative management and intensity of headache persistently worsening, one must have a neurologic examination followed by neuroimaging for timely diagnosis and treatment. Neostigmine/atropine is a choice drug for the management of severe headaches in post-dural puncture headaches after spinal anesthesia. Neostigmine/atropine was effective in treating PDPH after only a single dose. Although lacking robust evidence, use of a novel and non-invasive treatment when compared to an invasive procedure like an epidural blood patch certainly warrants more attention and future research.