CONCLUSION
In the context of severe headache not subsiding with conservative
management and intensity of headache persistently worsening, one must
have a neurologic examination followed by neuroimaging for timely
diagnosis and treatment. Neostigmine/atropine is a choice drug for the
management of severe headaches in post-dural puncture headaches after
spinal anesthesia. Neostigmine/atropine was effective in treating PDPH
after only a single dose. Although lacking robust evidence, use of a
novel and non-invasive treatment when compared to an invasive procedure
like an epidural blood patch certainly warrants more attention and
future research.