Quantifying the extent of drought and flood magnitude and frequency under the climate change impacts is essential for an effective water resource management. In this study, we utilize the Soil and Water Assessment Tool (SWAT) hydrological model, drought indices as well as the Interquartile Range (IQR) method for a comprehensive analysis of the river flow response to projected climate change scenarios. Four General Circulation Models (GCMs) under two Shared Socioeconomic Pathways (SSP2-4.5 and 5-8.5) have been used for our analysis (2023-2090). Our objective is to reveal the future projected drought and flood events in terms of intensity, frequency, and potential consequences for local livelihoods in the Srepok River basin (SRB), a tributary of the Mekong River basin (MRB), Southeast Asia. Our findings serve as the scientific basis for stakeholders and decisionmakers to develop adaptative strategies and sustainable plans to promote the region's resilience.