References:
1. Díez-Domingo J, Pérez-Yarza EG, Melero JA, Sánchez-Luna M, Aguilar MD, Blasco AJ, et al. Social, economic, and health impact of the respiratory syncytial virus: a systematic search. BMC infectious diseases . 2014;14:544.
2. Young M, Smitherman L. Socioeconomic Impact of RSV Hospitalization. Infectious diseases and therapy . 2021;10(Suppl 1):35-45.
3. Okada T, Matsubara K, Matsushima T, Komiyama O, Chiba N, Hamano K, et al. [Analysis of clinical features of community-acquired pneumonia caused by pediatric respiratory syncytial virus and human metapneumovirus]. Kansenshogaku zasshi The Journal of the Japanese Association for Infectious Diseases . 2010;84(1):42-47.
4. Mizuta K, Abiko C, Aoki Y, Ikeda T, Matsuzaki Y, Itagaki T, et al. Seasonal patterns of respiratory syncytial virus, influenza A virus, human metapneumovirus, and parainfluenza virus type 3 infections on the basis of virus isolation data between 2004 and 2011 in Yamagata, Japan. Japanese journal of infectious diseases . 2013;66(2):140-145.
5. Casalegno JS, Ottmann M, Bouscambert-Duchamp M, Valette M, Morfin F, Lina B. Impact of the 2009 influenza A(H1N1) pandemic wave on the pattern of hibernal respiratory virus epidemics, France, 2009. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin . 2010;15(6).
6. Achten NB, Wu P, Bont L, Blanken MO, Gebretsadik T, Chappell JD, et al. Interference Between Respiratory Syncytial Virus and Human Rhinovirus Infection in Infancy. The Journal of infectious diseases . 2017;215(7):1102-1106.
7. Nickbakhsh S, Mair C, Matthews L, Reeve R, Johnson PCD, Thorburn F, et al. Virus-virus interactions impact the population dynamics of influenza and the common cold.Proceedings of the National Academy of Sciences of the United States of America . 2019;116(52):27142-27150.
8. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.Lancet (London, England) . 2020;395(10229):1054-1062.
9. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. The New England journal of medicine . 2020;382(8):727-733.
10. Selin LK, Varga SM, Wong IC, Welsh RM. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. The Journal of experimental medicine . 1998;188(9):1705-1715.
11. Chan KF, Carolan LA, Korenkov D, Druce J, McCaw J, Reading PC, et al. Investigating Viral Interference Between Influenza A Virus and Human Respiratory Syncytial Virus in a Ferret Model of Infection. The Journal of infectious diseases . 2018;218(3):406-417.
Figure 1
Trends of RSV or hMPV infected patients under 10 years old who admitted in our hospital were shown. Before COVID-19 pandemic, the epidemic peaks of RSV and hMPV infections did not overlap in each year. In 2022 and 2023, the epidemic peaks of both infections completely overlapped.
Figure 2
The age distribution of RSV (upper graph) and hMPV (lower graph) infected patients in three different periods (2015-2017, 2018-2019, and 2021-2023) were presented. The age distribution of 2021-2023 period is shifted to right (arrows) compared to that of 2015-2017 and 2018-2019 and the mean age of 2021-2023 is significantly older (p<0.001: Mann-Whitney U test) than that of 2015-2017 and 2018-2019 in both RSV and hMPV infections.