Strengths and limitations of the study
This study has been conducted for the first time worldwide with 5
various genes related to the infectivity of SARS-CoV-2. This study, in
addition to investigating the effect of variants on contracting
COVID-19, the effect of found variants on the amino acid sequence of the
related proteins, and the structure and function of the related proteins
have been measured. This research confirms previous studies on the
importance of genetic factors predisposing to COVID-19 in ACE2, TMPRSS2,
TYK2, SLC6A20, and IFNAR2 genes. Some limitations of the study are that
first of all this study only focused on genetic factors, so all other
factors such as epigenetic factors, comorbidities, and lifestyle were
not considered. Second, for some polymorphisms that did not show any
association with contracting COVID-19, we cannot rule out the
possibility that they could be associated with disease severity or
death, perhaps larger sample sizes are needed to demonstrate this
association.