Introduction
Since its inception in 2019, coronavirus disease 2019 (COVID-19) rapidly became a pandemic affecting almost all the countries of the world. Prior studies including ours1 showed the effect of COVID-19 in hematopoietic cells causing lymphopenia, leukocytosis, neutrophilia, thrombocytopenia and leukoerythroblastosis. However, effect of COVID-19 and hematologic malignancies has not been reported widely. In this article, we are presenting two unique cases of B-lymphoblastic leukemia (B-ALL) in pediatric patients with a previous history of COVID-19 infection. Both the cases had complete resolution of COVID-19 infection during the time of presentation with acute leukemia.