Statins Strain methods & strategies Titer Ref.
Lovastatin A. terreus ATCC 20542 Adding KH2PO4, MgSO4·7H2O, NaCl and ZnSO4·7H2O to the medium 25.52 mg/L (Abd Rahim, Lim et al. 2019)
Adding 2mM or 5mM Zn2+ to the medium 49.2±1.4 mg gDCW-1 (Jia, Zhang et al. 2009)
Controlling higher redox potential during fermentation 83.8 mg/L (Pawlak and Bizukojc 2013)
Lactose is the initial substrate while feeding with glycerol 122.4 mg/L (Pecyna and Bizukojc 2011)
Glycerol is the initial substrate while feeding with lactose 161.8 mg/L (Pecyna and Bizukojc 2011)
The age of inoculated spores from 9 days to 16 days 186.5±20.1 mg/L (Porcel, López et al. 2006)
Carbohydrate concentration of jujube syrup 64 g/ L, yeast extract 15 g/L, PH 6.5, 150 rpm 241.1 mg/ L (Ansari, Jalili et al. 2018)
Adding10μm talc particles to the culture medium 250 mg/L (Gonciarz, Kowalska et al. 2016)
Soybean and peanut flours as substrate 250~280 mg/L (Rollini and Manzoni 2006)
The air bubbles diameter of bubble column bioreactor is 0.18cm 443 mg/L (Ansari, Jalili et al. 2019)
20% dissolved oxygen, 7 days of fermentation at 23 ℃ 572 mg/L (Lai, Tsai et al. 2005)
Adding 50 mg/L tylosin to the culture medium 952.7±24.3 mg/L (Jia, Zhang et al. 2010)
Adding 1% w/v coconut oil to the culture medium 87.18 g/ L (Sripalakit and Saraphanchotiwitthaya 2020)
A. terreus URM 5579 60 g/L soluble starch, 15 g/L soybean flour, pH 7.5, 200 rpm and 32 °C for 7 days 100.86 mg/L (Oliveira, Paulo et al. 2021)
P. ostreatus OBCC 1031 30 g/L glucose, 10 g/L yeast extract, 200 rpm, 28 ℃, and pH 6 114.82 mg/L (Atli, Yamaç et al. 2013)
M. purpureus MTCC 369 29.59 g/L glucose, 3.86 g/L NH4Cl, 1.73 g/L KH2PO4, 0.86 g/L MgSO4·7H2O and 0.19 g/L MnSO4·H2O 351 mg/L (Sayyad, Panda et al. 2007)
A. terreus KPR 12 Sago processing wastewater as substrate 429.98 mg/L (Srinivasan, Thangavelu et al. 2022)
A. terreus GD13 C:N ratio in the culture medium was 37:1; Seven days of fermentation 1342 mg/L (Kaur, Kaur et al. 2010)
Compactin P.citrinum NCIM 768 Using chemically-defined medium; Adding surfactant tween 80 175 mg/L (Chakravarti and Sahai 2002)
Glc 4.65 g/L, Gly 15.8 g/L, U 0.61 g/L; IA 4.24 days and HT 8.9 days 490 mg/L (Chakravarti and Sahai 2002)
A. terreus ATCC 20542 7 days fermentation with modified base medium (CLD); 14 days fermentation with standard medium (STD) 300~320 mg/L (Rollini and Manzoni 2006)
A. terreus Optimizing the medium constituents like glycerol, CuCl2·2H2O, FeSO4·7H2O, KH2PO4 and MgSO4·7H2O 701 mg/L (Syed and Rajasimman 2015)
P.citrinum MTCC 1256 7.0% glucose, 1.0% yeast extract and 0.1% MgSO4 390~410 mg/mL (Kónya, Jekkel et al. 1998)
Glycerol, peptone, yeast extract, MgSO4·7H2O and CaCl2·2H2O 589.3 mg/L (Ahmad, Panda et al. 2010)
P.citrinum L-18065 10 days of fermentation with 1.5 g/L triton X-100 1200 mg/L (Kumar, Srivastava et al. 2014)