Surfactants
Chakravarti et al.(Chakravarti and Sahai 2002) cultured the mutant strain of P. citrinum NCIM 768 in chemically-defined medium, producing 145 mg/L compactin. The titer of compactin was increased to 175 mg/L by adding surfactant tween 80 into the medium. Choi group(Choi, Cho et al. 2004) showed that compactin titer was 1200 mg/L after 10 days of fermentation with 1.5 g/L triton X-100, increased by 2-fold.