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levels and proposed that reactivity & durability of cellular response (
CD8+ cells) can prevent severe disease against viral variant even when
they escape from Nab. Equally, T-cell response at different time period
has also been studied in healthy individuals. 4,16,17But there is paucity of data in immunocompromised individuals for
sustained immune response especially with regards to T-cell-based
immunity. Cirrhosis is associated with impairment of innate and adaptive
immune system leading to acquired immunodeficiency. Both B and T-cell
mediated immunity is hampered in form of B and T-cell depletion and
dysfunction because of multifactorial causes like impaired production,
proliferation and increased apoptosis.18,19 Hence, we
selected patients of cirrhosis as immunocompromised population in our
study. We studied different subset of T-cell memory cells along with
antibody titer at baseline and at one year duration in vaccinated
healthy individuals and patients with liver cirrhosis at one year to
observe any difference in immune response.