Key Results
The rats in the doxorubicin-only group exhibited a significant decrease
in mitotic index and depleted GSH and antioxidants enzymes serum levels
with a significant elevation in MDA serum level, % DNA in Tail,
micronucleus appearance and chromosomal aberrations compared to the
control group; DMF pretreatment prior to doxorubicin exposure,
significantly-reduced % DNA in Tail, micronucleus appearance, and
chromosomal aberrations, improved mitotic index, restored GSH level and
antioxidant enzymes activity compared doxorubicin-only group.