3.2. Effect of DMF on Mitotic index (MI) and Chromosomal
Aberrations (CAs)
Table 1 showed that in Group II [rats orally administered DMF
alone (15mg/kg/day)], there was a non-significant difference in the
frequency of TCAs (P >0.05) in compassion toGroup I (control).
Furthermore, rats IP injected with a single dose of DOX (90mg/kg)
(Group III ) exhibited a significant increase(P <0.05) in the frequency of all structural CAs types,
total chromosome aberrations, and abnormal metaphases compared to the
control (Group I) rats.
However, in Group IV (DMF pre-treatment prior to DOX (90mg/kg)
exposure), there were significant reductions (P <0.05)
in the frequency of TCA, chromatid break, ring formation, and
chromosomal break compared to such frequency values in Group
III , with no significant change in the chromatid and chromosomal gap
appearance, chromosomal fragment deletion, acentric and dicentric
chromosome when compared to (Group III ) rats.
Concerning the mitotic index (MI), table 1 showed that there was a
non-significant difference in the percentage of MI
(P >0.05) in Group II rats (DMF alone) when
compared to the corresponding index in control (Group I ).
Moreover, in rats IP-injected with a single dose of DOX (Group
III ) there was a significant decrease (P <0.05) in the
MI value compared to the corresponding index in control (Group
I ).
However, in Group IV (DMF pre-treatment prior to DOX exposure),
there was a significant increase (P <0.05) in MI
compared to the corresponding index in Group III ( DOX only).