Conclusion
According to results obtained from this study, it can be concluded that oral administration of DMF (15mg/kg/day) alone has no DNA damaging effect or clastogenic activity. Its administration prior to IP injection of DOX improved the mitotic index and reduced the extent of DNA damage and chromosomal damage, and MN appearance in Wistar rats BM cells under the present experimental conditions; thus, DMF might be a potential chemoprotective agent against doxorubicin-induced adverse effect in cancer chemotherapy; consequently, DMF might help prevent reproductive abnormalities, secondary malignancy development and myelosuppression in cancer patients.