Experimental Approach
Wistar Albino rats of both sexes were administered DMF orally (15mg/kg once daily for 14 days) alone or with doxorubicin which was injected as a single dose (90 mg/kg at day 14) to induce toxicity. The blood samples were collected 24 hours after doxorubicin’s injection from all groups to measure the serum levels of MDA, GSH, SOD, and GPx1 and bone marrow was harvested to assess chromosomal aberration, micronucleus, and comet assays.