Conclusion
According to results obtained from this study, it can be concluded that
oral administration of DMF (15mg/kg/day) alone has no DNA damaging
effect or clastogenic activity. Its administration prior to IP injection
of DOX improved the mitotic index and reduced the extent of DNA damage
and chromosomal damage, and MN appearance in Wistar rats BM cells under
the present experimental conditions; thus, DMF might be a potential
chemoprotective agent against doxorubicin-induced adverse effect in
cancer chemotherapy; consequently, DMF might help prevent reproductive
abnormalities, secondary malignancy development and myelosuppression in
cancer patients.