Conclusion and Implication
This study revealed that DMF alone has no DNA-damaging or clastogenic activities; DMF has protective effects against the genotoxicity induced by doxorubicin; thus, DMF might be a potential chemoprotective agent against doxorubicin-induced toxicity in cancer chemotherapy.
Keywords: Doxorubicin; Dimethyl Fumarate; Genotoxicity; Chromosomal Aberration; Micronucleus assay; Comet assay.