Key learning point:
The etiology of the Leser-Trélat sign is unknown, it is likely that
viral infections like COVID-19 can be associated with eruptive
seborrheic keratosis,, although the exact pathogenesis is still not
clear.
Introduction
Covid-19 inection is caused by severe acute respiratory syndrome
coronavirus 2 [SARS-CoV-2], a Beta coronavirus. The most common
clinical manifestations of COVID-19 are respiratory symptoms. As the
pandemic progressed, other aspects were discovered, including cutaneous
manifestations of the disease for example erythematous rash, urticaria,
vesicle formation, and purpura. (2).
To date, no report has been made of the sudden eruption of seborrheic
keratoses following COVID-19 infection.
Sudden onset and rapid increase in size and/or number of seborrheic
keratoses is called the Leser-Trélat sign, suggesting a paraneoplastic
appearance of internal malignancy,(3). The most frequently associated
malignancies are adenocarcinoma of the colon, stomach, lung, or breast,
although the Leser-Trélat sign has also been reported in non-malignant
conditions, e.g., lepromatous leprosy, (4), erythrodermic pityriasis
rubra pilaris, (5), human immunodeficiency virus infection,(6), and
human papillomavirus infection.(7,). Leser-Trélat sign can also occur in
healthy individuals in the absence of internal malignancy. (8).
Herewith, we report a case of eruptive seborrheic keratoses, which
presented after recovery from COVID-19 infection in a 50-year-old man.