Conclusion
In this review, we have summarized the most frequently used epigenetic clocks as well as their applicability to childhood phenotypes, with a particular focus on asthma and allergic disease. EAA has been successfully used to link DNA methylation with disease onset. We focused on the study of epigenetic aging in asthma, and allergic disease and the potential of epigenetic clocks as a biomarker in asthma diagnosis. This review has shown the potential of epigenetic clocks as a tool in the study of aging beginning at birth and has identified areas for continued work. Novel clocks incorporating pediatric longitudinal data can help further characterize the connection between DNAm, asthma and epigenetic aging.