Conclusion
In this review, we have summarized the most frequently used epigenetic
clocks as well as their applicability to childhood phenotypes, with a
particular focus on asthma and allergic disease. EAA has been
successfully used to link DNA methylation with disease onset. We focused
on the study of epigenetic aging in asthma, and allergic disease and the
potential of epigenetic clocks as a biomarker in asthma diagnosis. This
review has shown the potential of epigenetic clocks as a tool in the
study of aging beginning at birth and has identified areas for continued
work. Novel clocks incorporating pediatric longitudinal data can help
further characterize the connection between DNAm, asthma and epigenetic
aging.