Epigenetic Clock Training Metrics
There are two types of epigenetic clocks – first and second-generation.
First-generation clocks use raw or log-transformed
CA53 as the dependent
variable, whereas a composite measure of aging is the dependent variable
in second generation clocks. For the composite measure, “proxies” of
biological aging, such as markers of heart and kidney function, are used
in addition to CA66.
These clocks are described in detail below.