Statistical Analysis
Descriptive data are reported as count (percent), mean (standard deviation), or median (interquartile range [IQR]), as appropriate. For group comparisons, Fisher’s exact test was used for categorical variables, the student t -test was used for normally distributed continuous variables, and the Krustal-Wallis test was used for skewed continuous variables, as appropriate. Statistical analysis was performed using R v4.1.1 (R Foundation, Vienna, Austria) in RStudio v1.4.1717. All tests were two-sided, and statistical significance was defined as p < 0.05.