Figure 9: Concept of the ideal process based on precipitation, tow stage filtration and flow through chromatography, data from (Burgstaller et al., 2019; Li et al., 2019) drawing courtesy G. Recanati.
By combing existing elements of continuous biomanufacturing with real-time monitoring concepts it is possible develop a fully automated system (Helgers et al., 2022; Vetter et al., 2021) which runs under optimal conditions without large safety margins it will run autonomously, and a real-time release concept could be realized.