Study population and data source
This study includes patients aged 21 years or younger at the time of
diagnosis who received an allogeneic transplant between
January 2007 and December 2017 at
our 457-bed children’s hospital in Phoenix, Arizona. QoL questionnaires
that capture patient readjustment were collected longitudinally using
the Pediatric Quality of Life Inventory Generic Score Scales (PedsQL TM
4.0) from 2013 to 2017. Patients were excluded if they did not have
post-transplant QoL data, as defined by a completed PedsQL TM 4.0, at
least two years after HSCT. Considering surveys of patients at least two
years after HSCT provided patients with sufficient time to experience
adjustments in QoL as expected in early post-HSCT life. For patients
with multiple transplants, transplant-specific data from the first
transplant was used, but the most recent PedsQL TM 4.0 was used for QoL
metrics. A total of 184 patients received HSCT at our hospital between
January 2007 and December 2017. Of this, 86 (46.7%) patients completed
the PedsQL TM 4.0, and were therefore included in the study. Of these
patients, 79 patients (91.86%) received one transplant and 7 patients
(8.14%) received two transplants. All patient demographic, treatment,
and transplant outcome data were obtained retrospectively through
medical chart review. All study procedures were approved by our
Institutional Review Board.